Biography of Vegener

Keywords: Vegener's granulomatosis, the history of Vegener's granulomatosis - systemic vasculitis from the group of necrotic, a distinctive feature of which is a characteristic immunological phenomenon: antibodies to the cytoplasm of ANCA neutrophils. Often debut with the involvement of the upper respiratory tracts of granulomas can also be localized in the bones of the facial skull, in particular orbits, in the future this disease is characterized by severe lung lesions that are often mistaken in pulmonary tissue in the progression of the pulmonary tissue.

The renal defeat for granulomatosis of the vegener often acquires all typical features of fast -extensive jade. Sometimes developing dramatically quickly, essentially full -minute, and for several days leading to death, today the granulomatosis of the vegener is almost completely controlled by immunosuppressive drugs. Along with glucocorticosteroids, which are still often the basis for the basis of treatment, cytostatics are widely used, primarily cyclophosphamide.

The experience of using vegener and more selective therapeutic strategies, in particular monoclonal antibodies to rituximab lymphocytes, is accumulated in granulomatosis of vegener. It can be argued that at present, the success of the treatment of granulomatosis of the vegener is determined primarily by the timeliness of the diagnosis of this disease, accessible not only with the help of intravital biopsy of the affected organs, but also due to the possibility of determining the serum titer of Anca in real clinical practice.

It is their detection that allows you to make a decision on the appointment of glucocorticosteroids and cytostatics, in t. This systemic vasculitis owes the name to its discoverer, German pathologist Friedrich Friedrich Wegener. In the city of Vegra, he reported this observation at the Congress of German Society of Pathologists, and in Frederick Vegener studied medicine in Munich, later in Kile.

Specializing in pathological anatomy, with the city of his mentor, Marin Smommler was one of the founders of the theory of racial hygiene, especially popular in National Socialist Germany. Of great interest, especially in recent decades, causes certain pages of the biography of Vegener, primarily his relationship with the National Socialist Party. Indeed, even in the city, B.

Mussolini, dressed in the brown uniform with an analogy with the Chernaroebashniki, the members of this association carried out the protection of Nazi events. With the city of Ram, in the future, the authority and influence in the company of this organization have significantly decreased and it began to be responsible only for the preparation of self -defense forces.

Supporters of the persecution of Vegener believe that his entry into the ranks of the brown -breeds was a conscious step, unlike many other figures of science, education and culture of Germany, who had to join the NSDAP in exchange for the possibility of continuing work. Starting to serve in the army, the veger received the title of Lt. Col. Working in the medical service of the Jewish ghetto Lodzi, the vegener obviously took part in the experiments on prisoners: for example, the fact of an autopsy was documented by him after the lifetime administration of oxygen into her vein in order to study the laws of the development of gas embolism.

It should be noted that the Jewish ghetto in Lodzi was formed with the aim of mass deportation of the Jews was supposed to give this city the status of Judenrein - free from Jews. With the participation of Vegener, from 50 to autopsy monthly performed. Wener fell ill with diphtheria, after recovery he continued to serve in the army until he entered American captivity. The veger was accused of war crimes and before G.

later he was engaged in mainly teaching and continued to work as a pathologist in Lubeck; Nevertheless, the majority opposed the abandonment of these eponims, rightly separating political beliefs from the scientific merits of the clinicians. The vegenera in the description of this disease is not disputed. It is also necessary to emphasize something else: the veger did not participate directly in the experiments on the prisoners of the ghetto and concentration camps, he only analyzed the morphological material obtained as a result.

Vegener's granulomatosis is today considered as one of the most commonly used models in the clinical practice to evaluate the effectiveness and safety of strategies for the treatment of systemic vasculitis and rapidly foregoing glomerulonephritis. With a timely start of treatment, remission is successfully achieved, often continuing for many years and ensuring a satisfactory quality of life.

The ANCA-Associated systemic necrotic vasculitis group also includes microscopic polyangita, however, the most common nosological form among them is still the option described by F. similar articles.